The San Francisco 49ers, who have several high-profile players dealing with injuries, will be an underdog in a regular-season game for the first time in 37 outings, when they face the Green Bay Packers at Lambeau Field on Sunday (4:15 p.m. ET, Fox).
The point spread sat around Green Bay -2 for most of the week, until Friday's news that QB Brock Purdy is out for San Francisco with right shoulder soreness. Packers -5.5 is the consensus line at top NFL betting sites as of Saturday morning. DE Nick Bosa is also out for the 49ers.
Journeyman backup Brandon Allen, who has a 2-7 career record, will start in place of Purdy. He hasn't thrown a pass in more than two years.
Odds for 49ers vs. Packers: Spread, total, moneyline for Week 12 clash
Here are live odds from top online sportsbooks.
The 49ers are 5-5 (4-6 against the spread), one game behind in the NFC West race. San Fran is 5-5 O/U. Green Bay is 7-3 SU (4-6 ATS) and 4-6 O/U.
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49ers vs. Packers injuries
Coach Kyle Shanahan said earlier in the week he expected Purdy to be ready for Sunday. BetMGM oddsmakers indicated the Packers would be favored by at least three more points if Purdy is ruled out.
The Packers (7-3) also have injury concerns, regarding RB Josh Jacobs (questionable, calf/quad) and star CB Jaire Alexander (knee), who managed to last only 10 plays last week at Chicago.
The weather forecast calls for temperatures in the low to mid-40s with a 40 percent chance of rain on Sunday in Green Bay.
49ers vs. Packers trends to know
1. Both defenses have caused headaches for QBs this season, with Green Bay holding two opponents to their worst game of the season (based on passer rating) and San Francisco three.
Both squads also are in the top-10 in turnover differential, Green Bay at plus-5 and San Francisco plus-
2. The 49ers and Packers hold the NFL record for most postseason meetings with 10. San Francisco has a 6-4 overall edge and is 5-0 since 2012. Included is last season's 24-21 victory at home in the divisional round as a 10.5-point choice.
3. Green Bay averaged 14.4 yards on its 17 pass plays last week (including one sack) in a 20-19 win at Chicago, the best rate in a game this season.
San Francisco, though, ranks fifth in the league in allowing only 6.5 yards a pass. And over its past eight games, that norm is 5.5.
Three things to watch: Love
1. Packers QB Jordan Love has been a big play waiting to happen in the eight games he has played. Love has tossed 11 interceptions, tied for most in the league. On the positive side, he has nine completions of 40-plus yards, tied for third-most with Purdy.
2. 49ers WR Jauan Jennings has been Purdy's favorite WR target since the injury to All-Pro Brandon Aiyuk in Week 7. Jennings caught 10 of 11 targeted throws last week.
3. In addition to Purdy and Bosa, other key 49ers on the injury report -- listed as questionable -- are OLT Trent Williams and TE George Kittle.
Williams, a first-team All-Pro 2021-23, hasn't missed a start this year, but has been dealing with a sore ankle this season. Kittle missed last week's game with a hamstring injury but said "for sure" he will play Sunday. Bosa, the team's sack leader, has hip and oblique issues.
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49ers vs. Packers prop bets and anytime TD scorer odds
For bettors seeking additional action besides who wins and by what score, there are many options. Here are prop bet offerings from top sports betting apps, including DraftKings, BetMGM and FanDuel. Caesars and Bet365 also have many prop markets
Anytime TD (DraftKings)
- 49ers RB Christian McCaffrey: -195
- Packers RB Josh Jacobs: -175
- 49ers WR Deebo Samuel: +115
- Packers WR Jayden Reed: +130
Any team to score 40 points (DraftKings)
- Yes: +650
- No: -1400
Total TDs (BetMGM)
- Under 3.5: +360
- Over 7.5: +375
Alternate spread (BetMGM)
- 49ers -8.5: +360
- Packers +8.5: -550
- 49ers +8.5: -375
- Packers -8.5: +270
Will there be overtime (FanDuel)
- Yes: +1300
- No: -4500
49ers vs. Packers betting predictions: San Francisco prevails
Editor's note: These predictions were made before Purdy was ruled out.
With the defending NFC champion 49ers having games remaining on their first-place schedule against Buffalo and Detroit, there might not be another team in the league with legitimate title aspirations more desperate for a victory.
Of course, it helps that RB Christian McCaffrey is back.
Prediction: 49ers +2; Under 47.5
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