Reece Walsh is set to be sidelined for at least one month with a knee injury.
Brisbane's star fullback sustained the injury during round 7's golden-point loss to the Warriors.
Walsh battled through to play the entirety of the match, but is now set to miss some time.
The day after, the Broncos confirmed the 22-year-old suffered a PCL injury.
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Reece Walsh knee injury: Origin opener unlikely for Broncos star
Walsh's injury is a considerable blow for both Brisbane and Queensland.
The Origin opener is scheduled for May 28, meaning Walsh is all but guaranteed to miss out on selection.
Even if he returns to the field in four weeks, that gives him just a week in camp with the Maroons.
Kalyn Ponga is now positioned as the strong favourite to take on the No. 1 jersey.
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Walsh has essentially ruled himself out of Origin 1 contention.
"No, probably not the first Origin," Walsh told News Corp during Magic Round week.
"But you never know how it (his knee) is feeling.
"It’s holding up pretty well at the moment but hopefully I can get through the rehab and see how we go."