A wave of shock wins, disastrous injuries and a handful of suspensions is sure to shake things up in the NRL for Round 5.
Penrith are staring down the barrel of four straight losses but could welcome Dylan Edwards and Nathan Cleary back to the fold, while South Sydney could be boosted by the return of Latrell Mitchell for their clash against the Sydney Roosters.
Manly will be forced to do without their talisman Tom Trbojevic after he was sidelined with a knee injury last week, with the likes of Brian To'o, Kayal Iro and Victor Radley joining him in the casualty ward.
Elsewhere, the Dolphins and Parramatta are the only remaining winless teams in the competition with Kristian Woolf and Jason Ryles already under mounting pressure.
MORE: NRL Injury List - All the latest news and updates
Canberra Raiders vs. Cronulla Sharks
(Thursday, April 3 at GIO Stadium, 8:00pm AEDT)
Canberra predicted team:
1. Kaeo Weekes
2. Savelio Tamale
3. Matthew Timoko
4. Seb Kris
5. Xavier Savage
6. Ethan Strange
7. Jamal Fogarty
8. Josh Papali'i
9. Tom Starling
10. Joe Tapine
11. Hudson Young
12. Matty Nicholson
13. Morgan Smithies
14. Owen Pattie
15. Corey Horsburgh
16. Trey Mooney
17. Ata Mariota
Raiders team news:
Kaeo Weekes endured a difficult night under the high ball against the Sharks but is set to keep his spot at fullback ahead of Chevy Stewart, who scored a try and clocked just under 200 run metres in reserve grade.
Josh Papali'i and Joe Tapine were put on report in Round 4 but have both avoided suspension, so will take their place in the starting side.
Corey Horsburgh, who has also avoided a ban, started at lock and Trey Mooney started up front against North Queensland but both men could drop to the bench to accommodate the return of Morgan Smithies.
The Englishman is likely to be named in his customary lock position after missing the Cowboys loss due to a head knock. Meanwhile, Papali'i was initially named to start in the front row but dropped to the pine in a late switch with Mooney.
Mooney and Simi Sasagi are likely to be competing for the final spot on the bench.
Cronulla predicted team:
1. Will Kennedy
2. Samuel Stonestreet
3. Jesse Ramien
4. Daniel Atkinson
5. Ronaldo Mulitalo
6. Braydon Trindall
7. Nicho Hynes
8. Addin Fonua-Blake
9. Blayke Brailey
10. Oregon Kaufusi
11. Briton Nikora
12. Teig Wilton
13. Cameron McInnes
14. Jayden Berrell
15. Tom Hazelton
16. Toby Rudolf
17. Tuku Hau Tapuha
Sharks team news:
Cronulla lost to Canterbury last week and saw two stars go down injured to give Craig Fitzgibbon some selection headaches.
Kayal Iro suffered a hamstring issue and will likely need to be replaced in the centres, while Sifa Talakai will miss at least one game after failing his HIA against the Bulldogs.
Daniel Atkinson could be promoted off the bench to take over from Iro, alternatively Mawene Hiroti could be drafted into the backline.
Tom Hazelton has missed the past three weeks with a back injury but could finally return to the bench to replace Talakai.
Jayden Berrell will be a leading contender to take the utility role on the pine if Atkinson is moved into the starting side.
Braden Hamlin-Uele remains sidelined with a knee injury, so Tuku Hau Tapuha will keep his place in the 17.
Penrith Panthers vs. North Queensland Cowboys
(Friday, April 4 at CommBank Stadium, 6:00pm AEDT)
Penrith predicted team:
1. Dylan Edwards
2. Paul Alamoti
3. Izack Tago
4. Thomas Jenkins
5. Casey McLean
6. Jack Cole
7. Nathan Cleary
8. Moses Leota
9. Mitch Kenny
10. Lindsay Smith
11. Luke Garner
12. Liam Martin
13. Isaah Yeo
14. Daine Laurie
15. Liam Henry
16. Isaiah Papali'i
17. Matthew Eisenhuth
Panthers team news:
Penrith are set to receive two massive boosts as they attempt to avoid an unprecedented fourth straight defeat.
Dylan Edwards is scheduled to return after missing the past few weeks, while Nathan Cleary should be back on deck after suffering a concussion in Round 3.
Daine Laurie will go back to the bench and act as the utility, while Brad Schneider will drop to the reserves.
Trent Toelau, who replaced Cleary at halfback during the loss to South Sydney, suffered a knee injury in the game and will not be available.
Tom Jenkins bumped Casey McLean out of the side in the centres and will likely keep his spot despite the loss, although McLean could be back in the side to replace the injured Brian To'o.
Scott Sorensen copped a head knock against the Bunnies and will be unavailable for this one with either Isaiah Papali'i, who started at prop in Round 4, or Luke Garner taking the vacant place in the backrow.
Lindsay Smith was named to start up front but dropped to the bench in a late switch last week. The prop will be named to start in this one, with Luron Patea or Matthew Eisenhuth likely to be the new face on the pine.
North Queensland predicted team:
1. Scott Drinkwater
2. Robert Derby
3. Jaxon Purdue
4. Viliami Vailea
5. Murray Taulagi
6. Tom Dearden
7. Jake Clifford
8. Jordan McLean
9. Reece Robson
10. Jason Taumalolo
11. John Bateman
12. Jeremiah Nanai
13. Reuben Cotter
14. Sam McIntyre
15. Kai O'Donnell
16. Griffin Neame
17. Coen Hess
Cowboys team news:
Todd Payten is likely to stick with the same 17 who got the job done against Canberra as the club grabbed their first win of the season.
South Sydney Rabbitohs vs. Sydney Roosters
(Friday, April 4 at Accor Stadium, 8:00pm AEDT)
South Sydney predicted team:
1. Latrell Mitchell
2. Jye Gray
3. Jack Wighton
4. Isaiah Tass
5. Mikaele Ravalawa
6. Cody Walker
7. Jamie Humphreys
8. Sean Keppie
9. Peter Mamouzelos
10. Tevita Tatola
11. Keaon Koloamatangi
12. Jai Arrow
13. Lachlan Hubner
14. Jayden Sullivan
15. Davvy Moale
16. Tallis Duncan
17. Siliva Havili
Rabbitohs team news:
Latrell Mitchell could return to the fold in a major boost for the Bunnies after the fullback has missed the opening month of the campaign with a hamstring injury.
If the star does return, Wayne Bennett could opt to shift Jye Gray to the wing after Alex Johnston's return proved short-lived as he picked up a shoulder issue against the Panthers.
Campbell Graham was sidelined with a calf injury last week and is likely to remain on the sidelines for the time being.
Tevita Tatola was promoted off the bench last week for Davvy Moale and could be named to start up front in Round 5.
Lachlan Hubner will return at lock after serving a two-match ban. He will replace Tallis Duncan, with the youngster going to the bench and Liam Le Blanc dropping out of the side.
Sydney predicted team:
1. James Tedesco
2. Daniel Tupou
3. Mark Nawaqanitawase
4. Robert Toia
5. Dom Young
6. Sandon Smith
7. Chad Townsend
8. Naufahu Whyte
9. Connor Watson
10. Lindsay Collins
11. Angus Crichton
12. Siua Wong
13. Nat Butcher
14. Zach Dockar-Clay
15. Spencer Leniu
16. Blake Steep
17. Salesi Foketi
Roosters team news:
Billy Smith continued his recovery from injury in the NSW Cup last week with the centre scoring a try and running for 100 metres during his side's win over Canberra. He will apply pressure on Robert Toia.
Connor Watson will be back on deck at hooker after missing Round 4 with concussion. He will take the No.9 jersey with Zach Dockar-Clay dropping to the bench and Hugo Savala going out of the side.
Spencer Leniu avoided a ban after being cited for a high shot during his side's loss to the Titans. Lindsay Collins could replace him in the starting side though after he returned from illness last week via the bench.
Victor Radley suffered a fractured cheekbone during his side's Round 4 defeat and will be out of the side with Nat Butcher potentially taking over at lock.
Salesi Foketi could return to the fold after serving his two-match suspension.
Parramatta Eels vs. St George Illawarra Dragons
(Saturday, April 5 at CommBank Stadium, 3:00pm AEDT)
Parramatta predicted team:
1. Isaiah Iongi
2. Sean Russell
3. Will Penisini
4. Zac Lomax
5. Josh Addo-Carr
6. Dylan Brown
7. Dean Hawkins
8. Joe Ofahengaue
9. Joey Lussick
10. Junior Paulo
11. Shaun Lane
12. Kitione Kautoga
13. J'maine Hopgood
14. Ryley Smith
15. Dylan Walker
16. Dan Keir
17. Sam Tuivaiti
Eels team news:
Bailey Simonsson played on the wing in the NSW Cup last week and ran for 159 metres, busted through six tackles and made two offloads as the Eels lost to the Sea Eagles. He will apply pressure to Sean Russell.
Jason Ryles may choose to throw recruit Dylan Walker straight into the side in the halves or use him off the bench after his arrival from the Warriors.
Joe Ofahengaue will continue up front after being promoted off the pine following Jack Williams' injury.
Charlie Guymer, Sam Tuivaiti and Dan Keir will be fighting to keep their spots in the 17.
St George Illawarra predicted team:
1. Clint Gutherson
2. Tyrell Sloan
3. Moses Suli
4. Valentine Holmes
5. Christian Tuipulotu
6. Kyle Flanagan
7. Lachlan Ilias
8. Toby Couchman
9. Damien Cook
10. David Klemmer
11. Luciano Leilua
12. Jaydn Su'A
13. Jack de Belin
14. Jacob Liddle
15. Blake Lawrie
16. Hamish Stewart
17. Dylan Egan
Dragons team news:
Shane Flanagan is unlikely to make any changes to his side other than enforced ones.
Emre Guler is looking at a lengthy suspension for a crusher tackle during his side's upset win over the Storm. Toby Couchman is likely to start up front alongside David Klemmer in his place.
Raymond Faitala-Mariner or Blake Lawrie could be restored to the 17 in Guler's absence.
Gold Coast Titans vs. Dolphins
(Saturday, April 5 at Cbus Super Stadium, 5:30pm AEDT)
Gold Coast predicted team:
1. Jaylan de Groot
2. Tony Francis
3. Brian Kelly
4. Phillip Sami
5. Jojo Fifita
6. AJ Brimson
7. Jayden Campbell
8. Mo Fotuaika
9. Sam Verrills
10. Reagan Campbell-Gillard
11. Klese Haas
12. Beau Fermor
13. Tino Fa'asuamaleaui
14. Chris Randall
15. David Fifita
16. Jaimin Jolliffe
17. Brock Gray
Titans team news:
Des Hasler is tipped to name a settled side after the Gold Coast claimed their second win on the bounce last week.
Jaylan de Groot got the nod at fullback after Keano Kini was ruled out for an extended period with a neck injury and the youngster will continue in the No.1 jersey.
Tony Francis will continue on the wing with Alofiana Khan-Pereira still sidelined with a hamstring issue.
Jaimin Jolliffe has missed the past two wins due to a calf injury he picked up in Round 2. If the prop is cleared to return, he could push Iszac Fa'asuamaleaui or Brock Gray off the bench.
Dolphins predicted team:
1. Hamiso Tabuai-Fidow
2. Jamayne Isaako
3. Jake Averillo
4. Herbie Farnworth
5. Jack Bostock
6. Kodi Nikorima
7. Isaiya Katoa
8. Daniel Saifiti
9. Jeremy Marshall-King
10. Felise Kaufusi
11. Kulikefu Finefeuiaki
12. Oryn Keeley
13. Max Plath
14. Kurt Donoghoe
15. Mark Nicholls
16. Ray Stone
17. Kenny Bromwich
Dolphins team news:
The Phins remain winless under Kristian Woolf and could now have to do without their skipper Tom Gilbert after he was cited for a high shot in Round 4.
If suspended, Max Plath could take over at lock with Oryn Keeley recalled on an edge. Alternatively, Ray Stone could be handed the No.13 jersey.
Kenny Bromwich was a late addition to the bench last week and could keep his spot ahead of Josh Kerr and the still injured Connelly Lemuelu.
Francis Molo is unlikely to be thrown straight into action after his move from the Dragons with Woolf revealing he would have to build up his fitness.
Brisbane Broncos vs. Wests Tigers
(Saturday, April 5 at Suncorp Stadium, 7:35pm AEDT)
Brisbane predicted team:
1. Reece Walsh
2. Selwyn Cobbo
3. Kotoni Staggs
4. Gehamat Shibasaki
5. Jesse Arthars
6. Ben Hunt
7. Adam Reynolds
8. Patrick Carrigan
9. Cory Paix
10. Payne Haas
11. Jack Gosiewski
12. Brendan Piakura
13. Kobe Hetherington
14. Billy Walters
15. Corey Jensen
16. Xavier Willison
17. Jaiyden Hunt
Broncos team news:
Jordan Riki is looking at two weeks on the sidelines after being cited for a high shot during his side's win over the Dolphins.
Brendan Piakura could replace him in the backrow with Jaiyden Hunt, Ben Te Kura and Martin Taupau in the fight to grab the vacant bench spot.
Wests Tigers predicted team:
1. Jahream Bula
2. Sunia Turuva
3. Adam Doueihi
4. Starford To'a
5. Jeral Skelton
6. Lachlan Galvin
7. Latu Fainu
8. Terrell May
9. Api Koroisau
10. Fonua Pole
11. Jack Bird
12. Alex Seyfarth
13. Alex Twal
14. Tallyn Da Silva
15. Royce Hunt
16. Tony Sukkar
17. Sione Fainu
Tigers team news:
Benji Marshall had to field an unfamiliar backline during the Tigers' loss to the Warriors with Jeral Skelton ruled out with a leg injury and Adam Doueihi then going down in the warm-up with a groin injury.
The injured duo could be back on deck for this one though with Jack Bird moving into the second row and Solomona Faataape dropping out of the side.
In a major blow, Jarome Luai has been hit with a one-match ban for a high tackle in Round 4. Latu Fainu could replace him at halfback.
Samuela Fainu suffered a leg injury against the Warriors and is expected to be sidelined with Bird likely to take his spot on an edge. Tony Sukkar could be the new face on the bench.
Manly Sea Eagles vs. Melbourne Storm
(Sunday, April 6 at 4 Pines Park, 4:05pm AEST)
Manly predicted team:
1. Lehi Hopoate
2. Jason Saab
3. Tolu Koula
4. Reuben Garrick
5. Clayton Faulalo
6. Luke Brooks
7. Daly Cherry-Evans
8. Josh Aloiai
9. Jazz Tevaga
10. Siosiua Taukeiaho
11. Haumole Olakau’atu
12. Ben Trbojevic
13. Jake Trbojevic
14. Jake Simpkin
15. Corey Waddell
16. Ethan Bullemor
17. Nathan Brown
Sea Eagles team news:
Tom Trbojevic is looking at a spell on the sidelines after suffering a knee injury against the Eels.
Lehi Hopoate will take over at fullback with Clayton Faulalo or Tommy Talau brought onto the wing.
Josh Aloiai is in doubt after struggling with an AC joint injury in Round 4. If the prop is ruled out, Nathan Brown is likely to take his place up front with Tof Sipley added to the pine.
Lachlan Croker is nearing a return after missing the opening month of the campaign with a knee injury. His inclusion would likely see Jake Simpkin drop out of the side.
Melbourne predicted team:
1. Ryan Papenhuyzen
2. Will Warbrick
3. Jack Howarth
4. Grant Anderson
5. Xavier Coates
6. Cameron Munster
7. Tyran Wishart
8. Stefano Utoikamanu
9. Harry Grant
10. Josh King
11. Shawn Blore
12. Eli Katoa
13. Trent Loiero
14. Bronson Garlick
15. Alec MacDonald
16. Tui Kamikamica
17. Nelson Asofa-Solomona
Storm team news:
Despite suffering a shock loss to the Dragons, Craig Bellamy is unlikely to make too many changes with Nick Meaney and Jahrome Hughes still sidelined.
However, the Storm will be boosted by the return of Nelson Asofa-Solomona, who will replace Marion Seve in the 17.
Canterbury Bulldogs vs. Newcastle Knights
(Sunday, April 6 at Accor Stadium, 6:15pm AEST)
Canterbury predicted team:
1. Connor Tracey
2. Blake Wilson
3. Bronson Xerri
4. Stephen Crichton
5. Marcelo Montoya
6. Bailey Hayward
7. Toby Sexton
8. Max King
9. Reed Mahoney
10. Daniel Suluka-Fifita
11. Josh Curran
12. Jacob Preston
13. Jaeman Salmon
14. Kurt Mann
15. Harry Hayes
16. Kurtis Morrin
17. Jack Todd
Bulldogs team news:
Cameron Ciraldo is set to name pretty much the same side which got the job done against Cronulla, with Jacob Kiraz, Matt Burton, Viliame Kikau and Sam Hughes still sidelined.
Reed Mahoney copped two charges for incidents during his side's win over the Sharks, although he is free to take his place at hooker this week.
Sitili Tupouniua will not feature though after he copped a one-match ban for a high tackle. Kurtis Morrin could replace him on the pine.
Newcastle predicted team:
1. Kalyn Ponga
2. James Schiller
3. Dane Gagai
4. Bradman Best
5. Greg Marzhew
6. Fletcher Sharpe
7. Jack Cogger
8. Jacob Saifiti
9. Phoenix Crossland
10. Brodie Jones
11. Dylan Lucas
12. Tyson Frizell
13. Adam Elliott
14. Jayden Brailey
15. Jack Hetherington
16. Mat Croker
17. Thomas Cant
Knights team news:
Fresh off the bye, Adam O'Brien will be looking for an improved showing from his side after their loss to the Titans in Round 3.
Leo Thompson and Kai Pearce-Paul are still unavailable, so Brodie Jones and Tyson Frizell are set to continue at prop and on an edge, respectively.
Dylan Lucas missed the loss to the Titans after suffering a hamstring strain although he could be back on deck for this one.
Jermaine McEwen could drop out as a result of his inclusion, while Thomas Cant will remain in the 17.