It hasn't been a pretty start to the season for North Queensland but they finally got into the winner's circle in Round 4 with a victory over Canberra.
Todd Payten's side will now look to build on this win by beating Penrith on Friday night.
The Cowboys beat the Panthers the last time they met in Round 17 last year as they rolled to a 16-6 win at the foot of the mountains.
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North Queensland Cowboys NRL game this week
The Cowboys will take on the Panthers at CommBank Stadium on Friday, April 4 at 6:00pm (AEDT).
Cowboys predicted team list vs. Panthers for Round 5
1. Scott Drinkwater
2. Robert Derby
3. Jaxon Purdue
4. Viliami Vailea
5. Murray Taulagi
6. Tom Dearden
7. Jake Clifford
8. Jordan McLean
9. Reece Robson
10. Jason Taumalolo
11. John Bateman
12. Jeremiah Nanai
13. Reuben Cotter
14. Sam McIntyre
15. Kai O'Donnell
16. Griffin Neame
17. Coen Hess
Cowboys latest team news for Round 5
Todd Payten is likely to stick with the same 17 who got the job done against Canberra as the club grabbed their first win of the season.
Robert Derby took over from Braidon Burns on the wing and will remain in the team with Burns still sidelined.
Viliami Vailea will likely keep Zac Laybutt at bay in the centres with the latter continuing to ease back from an ACL injury in the QLD Cup.