NFL Playoffs odds, Super Bowl 59 best bets, favorites to win AFC and NFC Championship

The brackets for the 2025 NFL Playoffs have been set, and the opening odds have gone live for Super Bowl 59 as well as the AFC and NFC Championships. 

Surprise, surprise: the reigning-champion Chiefs sit among the favorites to once again win it all. After an improbable 15-2 regular season, Patrick Mahomes, Travis Kelce and Andy Reid's squad will be vying to become the first team to win three straight Super Bowls. 

Kansas City isn't the favorite, though. That distinction has been earned by Dan Campbell's Lions, who finished No. 1 in the NFC after a commanding Week 18 victory over the Vikings. Despite its myriad injuries, Detroit has looked like the class of the NFL all season. 

Of course, nobody will want to overlook two-time MVP Lamar Jackson, Derrick Henry and the Ravens, MVP favorite Josh Allen and the Bills, or Offensive Player of the Year lock Saquon Barkley and the Eagles. Dark horses exist, too, including the Packers, Bucs, and Rams.

Let's take a look at the odds for Super Bowl 59 as well as the AFC and NFC Championships, then unveil the best bets to make and win the 2025 Super Bowl. 

Super Bowl 59 odds

All odds courtesy of Sports Interaction.

To nobody's surprise, the Lions (+280) and Chiefs (+350) serve as the heaviest favorites after winning the No. 1 seed and earning first-round byes. Three other powerhouses join them, though, with the Ravens, Bills and Eagles all opening at 7-to-1 odds or shorter. 

A steep drop-off occurs from there, with the Vikings and Packers at 16-to-1 and 18-to-1 and no other squad shorter than 30-to-1. The Texans, Broncos and Steelers, three 10-7 teams, serve as massive long-shots due to injuries, inexperience and inconsistencies during the home stretch of the regular season. 

Super Bowl 59: Best bet to win

Buffalo Bills (+600)

Nobody seems to be betting them, but Josh Allen and the Bills are quite easily the best value to win it all entering the 2025 NFL Playoffs. Allen has done it all this season, consistently proving that he has taken a big step forward as a franchise QB. 

Take away the punted Week 18 loss to the Patriots (with Allen and other starters resting), and Buffalo went 10-1 with Allen under center to finish the season. That included wins over the defending-champion Chiefs and the NFC-leading Lions, and the one loss was a 44-42 barn-burner against the Rams in LA. 

The biggest positive for Buffalo: home-field advantage against every AFC team except Kansas City. The Chiefs have looked like the most beatable 15-2 team in NFL history this season, and the Bills already took them out 30-21 in mid-November. Could this be the year that Allen finally gets past Mahomes?

Of course, the biggest in-conference threat is Baltimore. Lamar Jackson has looked better than he did in his two MVP campaigns, and he now has two-time rushing champ Derrick Henry on top of a healthy Zay Flowers and Mark Andrews. The Ravens beat Buffalo 35-10 in late September, but Orchard Park in January might be a different story.

NFC Championship 2025: Best bet to win

Philadelphia Eagles (+350)

Considering Jalen Hurts, Saquon Barkley and the Eagles went 12-1 to finish the regular season, they sure seem to be flying under the radar. Most sportsbooks list Philly with the fifth-shortest Super Bowl odds and about a 22-percent implied probability to win the NFC title. 

Detroit enters the playoffs with a huge list of injuries to key players, while Nick Sirianni's squad has only a couple health concerns entering the postseason. With A.J. Brown, DeVonta Smith, and now potentially even Dallas Goedert active, Barkley playing the best ball of his career, and Hurts not throwing a pick since Nov. 10, the sky's the limit.

The biggest catalyst for this Eagles team, though, might be its defense. Philadelphia held opponents to 20 points or fewer in 10 of its final 13 games of the regular season, and also ranked first in the NFL in total yards allowed (278.4 per game) and yards allowed at home (259.9).

The play of the Eagles' big-time skill-position players make this squad a contender once again. But a stifling D, a still-solid offensive line, and home-field advantage against all but one NFC team could contribute to Philly's fifth-ever Super Bowl berth and third in the past eight years.