In-form Chelsea will fancy their chances of continuing a recent winning run as they head to Premier League strugglers Southampton.
Enzo Maresca's Blues are on a three-game winning streak in all competitions, and sit in third place in the league table, with a near-identical record to second-placed Arsenal after 13 games played.
Russell Martin's Saints, meanwhile, are rock bottom with five points and just one win in 2024/25. However, their efforts in recent games have exceeded their returns, and they enter this tough fixture with nothing to lose and, perhaps, a bit of good luck overdue.
The Sporting News looks at the latest team news and confirmed lineups for this fixture at St Mary's Stadium.
MORE: All the latest Chelsea news | Premier League schedule for 2024/25 | Latest Premier League top scorer rankings
Southampton vs. Chelsea lineups, predicted starting 11, team news
Not helping Southampton's current plight is their injury pile-up. Goalkeeper Aaron Ramsdale's hand injury won't be cleared up until closer to Christmas, while Adam Lallana is projected to miss a few more games with a thigh strain.
Jan Bednarek, Ross Stewart, Paul Onuachu and William Smallbone all miss out for Chelsea's visit and Gavin Bazunu's Achilles rupture makes him a long-term absentee.
Lesley Ugochukwu will not be able to face his parent club, while key trio Tyler Dibling, Taylor Harwood-Bellis and Flynn Downes are suspended due to yellow-card accumulation.
Southampton lineup (5-4-1, right to left): Lumley (GK) — Walker-Peters, Bree, Stephens, Wood, Manning — Armstrong, Aribo, Fernandes, Fraser — Archer
Injured: Ramsdale Lallana, Bednarek, Stewart, Onuachu, Smallbone, Bazunu.
Suspended: Dibling, Harwood-Bellis, Downes.
Ineligible: Ugochukwu
MORE: All the latest EPL club news | Team-by-team Premier League schedule for 2024/25 | Latest Premier League top scorer rankings
Chelsea, meanwhile, have fewer players out and a far deeper squad to choose from.
However, three players do miss out, all thanks to hamstrings issues as Reece James, Omari Kellyman and Wesley Fofana face weeks on the sidelines.
Maresca makes multiple changes from the 3-0 win at Aston Villa last time out with starts in attack for Christopher Nkunku and Joao Felix - plus a shock spot for Filip Jorgensen in goal, in place of Robert Sanchez.
Chelsea lineup (4-2-3-1, right to left): Jorgensen (GK) — Gusto, Tosin, Disasi, Cucurella — Caicedo, Fernandez — Madueke Palmer, Felix — Nkunku.
Injured: James, Kellyman, Fofana.
Suspended: None
Southampton vs. Chelsea live stream, TV channel
Here's how to watch this Premier League match across selected areas of the world's major regions:
| Region | TV | Streaming |
| USA | — | Peacock |
| Canada | — | Fubo |
| UK | — | Amazon Prime |
| Australia | — | Optus Sport |
| India | — | Disney + Hotstar, JioTV |
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