NFL Week 4 betting odds, lines, point spreads and over/under totals for every 2024 football game

Sloan Piva

NFL Week 4 betting odds, lines, point spreads and over/under totals for every 2024 football game image

Autumn has officially begun, and the 2024 NFL season surges forward — while the majority of survivor pool entries have been stopped dead in their tracks. Every weekend, a wilder betting storyline seems to take form. What could possibly lie on the horizon in Week 4?

The Sporting News, as it has all season, will have you covered all week with up-to-date moneyline, spread, and over/under odds for all 16 games on the Week 4 slate. That way, you can identify early value, pinpoint day-to-day shifts, and monitor wagering and pricing trends throughout the week. 

MORE: Mike McCarthy on Cowboys coaching hot seat | Early-season surprises

This week features plenty of close matches, including Bears-Rams, Vikings-Packers, and Eagles-Bucs. However, two lopsided spreads stick out on Week 4's opening market: the 49ers -10.5 vs. the Patriots and the Jets -8 vs. the Broncos.

Do your research before locking in a bet on a heavy favorite! The Pats upset the Bengals in Week 1, and the Broncos bested the Bucs in Week 3. Underdogs also dominated Week 2 with 10 covers and eight straight-up wins, including the Raiders over the Ravens and the Falcons over the Chiefs, both fourth-quarter comeback wins.

What's next in the wild world of NFL betting? Let's get to the BetMGM odds for Week 4 of the 2024 season, including the moneyline, spread, and over/under pricing for all 16 games. Good luck, have fun, and follow your instincts!

NFL Week 4 odds: Lines, spreads, over/under totals

All odds courtesy of BetMGM

Day/time (ET)GameMLATSO/U
Thu, 9/26
8:15 p.m.
Cowboys @
Giants
DAL -225
NYG +185
DAL -4.5 (-115)
NYG +4.5 (-105)
O 43.5 (-110)
U 43.5 (-110)
Sun., 9/29
1:00 p.m.
Bengals @
Panthers
CIN -250
CAR +200
CIN -5.5 (-110)
CAR +5.5 (-110)
O 44.5 (-110)
U 44.5 (-110)
Sun., 9/29
1:00 p.m.
Broncos @
Jets
NYJ -400
DEN +325
NYJ -8 (-110)
DEN +8 (-110)
O 38.5 (-110)
U 38.5 (-110)
Sun., 9/29
1:00 p.m.
Jaguars @
Texans
HOU -225
JAX +185
HOU -4.5 (-115)
JAX +4.5 (-105)
O 45.5 (-110)
U 45.5 (-110)
Sun., 9/29
1:00 p.m.
Rams @
Bears
CHI -120
LAR +100
CHI 1.5 (+100)
LAR +1.5 (-120)
O 40.5 (-110)
U 40.5 (-110)
Sun., 9/29
1:00 p.m.
Vikings @
Packers
GB -145
MIN +120
GB -2.5 (-110)
MIN +2.5 (-110)
O 43.5 (-115)
U 43.5 (-105)
Sun., 9/29
1:00 p.m.
Eagles @
Buccaneers
PHI -145
TB +120
PHI -2.5 (-110)
TB +2.5 (-110)
O 45.5 (-105)
U 45.5 (-115)
Sun., 9/29
1:00 p.m.
Steelers @
Colts
PIT -125
IND +105
PIT -1.5 (-115)
PIT +1.5 (-105)
O 38.5 (-110)
U 38.5 (-110)
Sun., 9/29
4:05 p.m.
Patriots @
49ers
SF -600
NE +450
SF -10.5 (-110)
NE +10.5 (-110)
O 40.5 (-110)
U 40.5 (-110)
Sun., 9/29
4:05 p.m.
Commanders 
@ Cardinals
ARI -225
WAS +190
ARI -5 (-110)
WAS +5 (-110)
O 49 (-110)
U 49 (-110)
Sun., 9/30
7:30 p.m.
Titans @ 
Dolphins
TEN -115
MIA -105
TEN -1.5 (+100)
MIA +1.5 (-120)
O 37.5 (-110)
U 37.5 (-110)
Sun., 9/30
8:15 p.m.
Seahawks @
Lions
DET -210
SEA +170
DET -4.5 (-105)
SEA +4.5 (-115)
O 47.5 (-110)
U 47.5 (-110)

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Sloan Piva

Sloan Piva Photo

Sloan Piva is a content producer for The Sporting News, primarily focused on betting, fantasy sports, and poker. A lifelong New Englander, Sloan earned his BA and MA in Journalism from the University of Massachusetts and now lives in coastal Rhode Island with his wife and two kids.